Co-Culture
Stable co-culture of human cells and microbes
A new class of Microbiome
discovery platform
IMAT
A precision microfluidic instrument engineered to sustain stable cultures of microbial communities and gut cells — unlocking bi-directional signaling and physiological relevant experiments
The platform
Automation
Automated microfluidic control enabling reproducible parallel experiments
Bioinformatics
Integrated data and analysis platform enabling microbiome insights and discovery
MV-Reactor
High-Throughput Microbial Screening
The MV-Reactor cartridge is designed for fast, cost-efficient in vitro screening of microbial communities and compounds under gut-like conditions.
Key features
- Single-chamber design for high-throughput experiments
- Maintains strict anaerobic or aerobic environments
- Ideal for testing probiotics, postbiotics, and antimicrobials
- Compatible with human, animal, and synthetic microbiota
- Optimised for faecal fermentation studies
Applications
- Microbiome screening pipelines
- Batch testing for product development
- Safety and efficacy profiling of novel ingredients
Single-chambermicroGUT
A Multi-Stage Gut-On-Chip Cartridge
microGUT is a modular, multi-compartment cartridge that mimics the entire human colon and small intestine, providing a dynamic, spatially resolved simulation of the gut.
Key features
- Models 4 gut regions (SI, AC, TC, DC) with independent control of flow and pH
- Spiral chambers for realistic nutrient gradients and retention time
- Plug-and-play with the IMAT automation core
- Supports complex, long-term microbial colonisation
Applications
- Studying microbiome-host-diet interactions
- Mapping drug and nutrient metabolism across the gut
- Understanding microbial succession and functional shifts
- Comparing different diets or treatment regimes in a time-resolved setup
Multi-stage cartridgeCo-culture
Microbiome & Host Cell Interactions
Our Co-Culture Module enables direct interaction studies between live microbial ecosystems and human gut epithelial cells, advancing the frontier of in vitro human models.
Key features
- Two-chamber system with a semipermeable membrane interface
- Maintains differential oxygen and nutrient gradients
- Mimics the mucosal interface of the human gut
- Enables measurement of host responses (e.g., cytokines, barrier integrity)
Applications
- Gut barrier and inflammation studies
- Microbial metabolite-host cross-talk
- Preclinical screening of therapeutics and functional foods
- Immune and metabolic response assays
Co-cultureReal world impact
What do we test?
Ingredients
Full product testing to individual ingredient
Prebiotics
Testing of viability and mode of action
Drug-microbiome interaction
Testing of drug interactions with the gut microbiome
Types of microbiome
Human
Healthy donors fully categorised, along with metabolic data
Infant
Human infant microbiome profiles with industry relevance
Animal
Feasibility of adapting system to multiple animal gut microbiomes
High throughput
Cost efficient- Human relevant interactions
Biohub
We turn complex microbiome data into actionable intelligence, learning from every project to build a proprietary knowledge base
Bioinformatics &
Analytical Modeling
Data Sequencing
Amplicon (16S, ITS), or RAW files and let us handle the analysis workflow
Data Analysis
Transform data into meaningful microbiome insights to improve discovery, directly and beyond
Knowledge Hub
Deploy an ever-growing hub of microbiome research, references, and emerging insights
The pipeline
Sequencing data
- Amplicon 16S, ITS
- Shotgun metagenomics (Illumina NGS)
- Metabolomics (optional/on-demand)
Bioinformatics processing
- Quality check
- Taxonomy profiling
- Functional profiling
- Custom analysis (on-demand)
Downstream analysis
- Statistical analysis
- Ecological metrics
- Custom analysis (on-demand)
Why Choose BIOHUB's Pipeline?
Automated & Scalable
Process 10 to 1,000+ samples with consistent, reproducible pipelines
Flexible Customisation
From standard analyses for Metagenomics and Microbiomics to fully bespoke workflows
Integrated Shotgun & Amplicon
Seamlessly combines taxonomy, diversity, and functional insights in one platform
Multi-Omics Enabled
Integrate omics data and metadata seamlessly across projects
Ecological & Metabolic Modelling
Novel topical analyses for microbiome inference and community simulation
Publication Ready
Traceable workflows, version controls, and outputs ready for publication